diff --git a/src/libsigrok-internal.h b/src/libsigrok-internal.h
index 75c91e92..b614c93d 100644
--- a/src/libsigrok-internal.h
+++ b/src/libsigrok-internal.h
@@ -1759,6 +1759,8 @@ SR_PRIV int std_cg_idx(const struct sr_channel_group *cg, struct sr_channel_grou
 SR_PRIV int std_dummy_set_params(struct sr_serial_dev_inst *serial,
 	int baudrate, int bits, int parity, int stopbits,
 	int flowcontrol, int rts, int dtr);
+SR_PRIV int std_dummy_set_handshake(struct sr_serial_dev_inst *serial,
+	int rts, int dtr);
 
 /*--- resource.c ------------------------------------------------------------*/
 
@@ -1843,6 +1845,8 @@ SR_PRIV int serial_set_read_chunk_cb(struct sr_serial_dev_inst *serial,
 		serial_rx_chunk_callback cb, void *cb_data);
 SR_PRIV int serial_set_params(struct sr_serial_dev_inst *serial, int baudrate,
 		int bits, int parity, int stopbits, int flowcontrol, int rts, int dtr);
+SR_PRIV int serial_set_handshake(struct sr_serial_dev_inst *serial,
+		int rts, int dtr);
 SR_PRIV int serial_set_paramstr(struct sr_serial_dev_inst *serial,
 		const char *paramstr);
 SR_PRIV int serial_readline(struct sr_serial_dev_inst *serial, char **buf,
@@ -1883,6 +1887,8 @@ struct ser_lib_functions {
 	int (*set_params)(struct sr_serial_dev_inst *serial,
 			int baudrate, int bits, int parity, int stopbits,
 			int flowcontrol, int rts, int dtr);
+	int (*set_handshake)(struct sr_serial_dev_inst *serial,
+			int rts, int dtr);
 	int (*setup_source_add)(struct sr_session *session,
 			struct sr_serial_dev_inst *serial,
 			int events, int timeout,
diff --git a/src/serial.c b/src/serial.c
index 8ffba795..34d7cbea 100644
--- a/src/serial.c
+++ b/src/serial.c
@@ -561,6 +561,37 @@ SR_PRIV int serial_set_params(struct sr_serial_dev_inst *serial,
 	return ret;
 }
 
+/**
+ * Manipulate handshake state for the specified serial port.
+ *
+ * @param serial Previously initialized serial port structure.
+ * @param[in] rts Status of RTS line (0 or 1; or -1 to ignore).
+ * @param[in] dtr Status of DTR line (0 or 1; or -1 to ignore).
+ *
+ * @retval SR_OK Success.
+ * @retval SR_ERR Failure.
+ *
+ * @private
+ */
+SR_PRIV int serial_set_handshake(struct sr_serial_dev_inst *serial,
+	int rts, int dtr)
+{
+	int ret;
+
+	if (!serial) {
+		sr_dbg("Invalid serial port.");
+		return SR_ERR;
+	}
+
+	sr_spew("Modifying serial parameters on port %s.", serial->port);
+
+	if (!serial->lib_funcs || !serial->lib_funcs->set_handshake)
+		return SR_ERR_NA;
+	ret = serial->lib_funcs->set_handshake(serial, rts, dtr);
+
+	return ret;
+}
+
 /**
  * Set serial parameters for the specified serial port from parameter string.
  *
diff --git a/src/serial_bt.c b/src/serial_bt.c
index 42d6289a..9d7cfb2b 100644
--- a/src/serial_bt.c
+++ b/src/serial_bt.c
@@ -816,6 +816,7 @@ static struct ser_lib_functions serlib_bt = {
 	 * here, since the caller will cache/register them already.
 	 */
 	.set_params = std_dummy_set_params,
+	.set_handshake = std_dummy_set_handshake,
 	.setup_source_add = ser_bt_setup_source_add,
 	.setup_source_remove = ser_bt_setup_source_remove,
 	.list = ser_bt_list,
diff --git a/src/serial_hid.c b/src/serial_hid.c
index 0db5cab5..eccdf0f2 100644
--- a/src/serial_hid.c
+++ b/src/serial_hid.c
@@ -1340,6 +1340,7 @@ static struct ser_lib_functions serlib_hid = {
 	.write = ser_hid_write,
 	.read = ser_hid_read,
 	.set_params = ser_hid_set_params,
+	.set_handshake = std_dummy_set_handshake,
 	.setup_source_add = ser_hid_setup_source_add,
 	.setup_source_remove = ser_hid_setup_source_remove,
 	.list = ser_hid_list,
diff --git a/src/serial_libsp.c b/src/serial_libsp.c
index f5a2b74b..bfdc3202 100644
--- a/src/serial_libsp.c
+++ b/src/serial_libsp.c
@@ -280,6 +280,30 @@ static int sr_ser_libsp_set_params(struct sr_serial_dev_inst *serial,
 	return SR_OK;
 }
 
+static int sr_ser_libsp_set_handshake(struct sr_serial_dev_inst *serial,
+	int rts, int dtr)
+{
+	int ret;
+
+	if (!serial->sp_data) {
+		sr_dbg("Cannot configure unopened serial port %s.", serial->port);
+		return SR_ERR;
+	}
+
+	if (rts >= 0) {
+		ret = sp_set_rts(serial->sp_data, rts ? SP_RTS_ON : SP_RTS_OFF);
+		if (ret != SP_OK)
+			return SR_ERR;
+	}
+	if (dtr >= 0) {
+		ret = sp_set_dtr(serial->sp_data, dtr ? SP_DTR_ON : SP_DTR_OFF);
+		if (ret != SP_OK)
+			return SR_ERR;
+	}
+
+	return SR_OK;
+}
+
 #ifdef G_OS_WIN32
 typedef HANDLE event_handle;
 #else
@@ -494,6 +518,7 @@ static struct ser_lib_functions serlib_sp = {
 	.write = sr_ser_libsp_write,
 	.read = sr_ser_libsp_read,
 	.set_params = sr_ser_libsp_set_params,
+	.set_handshake = sr_ser_libsp_set_handshake,
 	.setup_source_add = sr_ser_libsp_source_add,
 	.setup_source_remove = sr_ser_libsp_source_remove,
 	.list = sr_ser_libsp_list,
diff --git a/src/std.c b/src/std.c
index d1e2eedf..81f269fa 100644
--- a/src/std.c
+++ b/src/std.c
@@ -928,3 +928,12 @@ SR_PRIV int std_dummy_set_params(struct sr_serial_dev_inst *serial,
 	return SR_OK;
 }
 
+SR_PRIV int std_dummy_set_handshake(struct sr_serial_dev_inst *serial,
+	int rts, int dtr)
+{
+	(void)serial;
+	(void)rts;
+	(void)dtr;
+
+	return SR_OK;
+}