diff --git a/react/features/toolbox/components/AudioMuteButton.js b/react/features/toolbox/components/AudioMuteButton.js
index 41d982e55..458ae7158 100644
--- a/react/features/toolbox/components/AudioMuteButton.js
+++ b/react/features/toolbox/components/AudioMuteButton.js
@@ -109,6 +109,11 @@ class AudioMuteButton extends AbstractAudioMuteButton<Props, *> {
      * @returns {void}
      */
     _onKeyboardShortcut() {
+        // Ignore keyboard shortcuts if the audio button is disabled.
+        if (this._isDisabled()) {
+            return;
+        }
+
         sendAnalytics(
             createShortcutEvent(
                 AUDIO_MUTE,
diff --git a/react/features/toolbox/components/VideoMuteButton.js b/react/features/toolbox/components/VideoMuteButton.js
index 093213ccc..914d4b3b1 100644
--- a/react/features/toolbox/components/VideoMuteButton.js
+++ b/react/features/toolbox/components/VideoMuteButton.js
@@ -135,6 +135,11 @@ class VideoMuteButton extends AbstractVideoMuteButton<Props, *> {
      * @returns {void}
      */
     _onKeyboardShortcut() {
+        // Ignore keyboard shortcuts if the video button is disabled.
+        if (this._isDisabled()) {
+            return;
+        }
+
         sendAnalytics(
             createShortcutEvent(
                 VIDEO_MUTE,